What does uremia refer to?

Uremia refers to the build-up of waste products in the blood that occurs when the kidneys are not functioning properly. This condition is typically associated with kidney failure or significant impairment in kidney function, where the kidneys cannot adequately filter and excrete waste products, leading to their accumulation in the bloodstream. The symptoms of uremia can include fatigue, nausea, confusion, and other serious health issues, underscoring the importance of the kidneys in maintaining the body's overall homeostasis. This context highlights why the correct answer focuses on the accumulation of waste in the blood, providing a comprehensive understanding of the term and its implications for patient care.